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4-residue chain

Epitalon

Ala-Glu-Asp-Gly tetrapeptide from the Khavinson group; community longevity use

5MG
Dose
50U
Draw
10D
Cycle

Epitalon (epithalon, AEDG) is a synthetic tetrapeptide derived from the pineal extract epithalamin. It is not FDA-approved. No label or independent trial dose exists; the 'Russian-style' course below is community practice from one secondary report.

PTSEALEDEpitalon10 MGLYOPHILIZED

Protocols

  • Short community courserecommended

    Community practice, not from a label or trial: low end of the 5-10 mg/day, 10-20 day range.

  • Longer, upper-range community course

    Community practice, not from a label or trial: top of the stated range (10 mg/day for 20 days).

Dosing

  • Community practice, not from a label or trial: 5-10 mg/day subcutaneously, once daily, for 10-20 days, 1-2 cycles per year (Outliyr).
  • Community practice, not from a label or trial: 'biohacker maintenance' 10 mg/day, often in the evening, 10-20 days, twice a year.
  • Sublingual and nasal use (higher mg, 50-100 mg/day sublingual) is reported, but the source says no clinical data supports it; not encoded.

Route & timing

Route: Subcutaneous injection of a reconstituted lyophilized powder (community). The older human work was on epithalamin, the pineal extract, not synthetic epitalon (Outliyr).

Timing: Once daily, often evening (community).

Reconstitution

  • Lyophilized powder with bacteriostatic water; no sourced volume or storage temperature.
  • The water in the protocols is arithmetic for a readable draw: a 10 mg vial in 1 mL gives 10 mg/mL, so 5 mg = 50 units and 10 mg = 100 units in a 100-unit syringe. Not a sourced instruction.

Reconstitution calculator

Concentration
10 mg/mL
Per unit
0.1 mg
Draw
50 units
Volume
0.5 mL
Doses per vial
2
Vials for cycle (10 doses), pooled
5
Vials, discard remainder
5
concentration = 10 / 1 = 10 mg/mL
per unit = 10 / 100 = 0.1 mg
units = 5 / 0.1 = 50
mL = 50 / 100 = 0.5
doses per vial = 10 / 5 = 2
pooled vials = ceil(5 x 10 / 10) = 5
discard vials = ceil(10 / floor(2)) = 5

Stability

No reliable figure found in the sources; ask your prescriber or supplier.

Off-cycle

1-2 courses per year (community), so roughly 26-52 weeks between courses.

Why:

  • The weeks are derived from the stated 1-2 cycles per year; the source gives no explicit rest period.

Stacking rules

  • Never draw into the same syringe as another compound; use separate syringes and distinct injection sites.

Safety

Not FDA-approved. Registered or used in parts of the Russian medical system (Outliyr). Gray-market peptide in the US and EU; no quality oversight.

Common side effects:

  • Injection-site redness and transient swelling; occasional mild fatigue (Outliyr; community reports, not trial data).

Stop and call your prescriber if:

  • Injection-site infection
  • New severe headache or neurological symptoms
  • A theoretical cancer concern (telomerase/ALT activity) is raised but not shown to be harmful; avoid if pregnant, breastfeeding, under 18 or at high cancer risk without clinician oversight.

Labs and monitoring:

  • No monitoring schedule was found in the sources.

Markers to track

No reliable source names a biomarker for this compound.

Sources

Epitalon