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7-residue chain

Semax

ACTH(4-7)-derived heptapeptide; registered in Russia as a nasal nootropic

300MCG
Dose
12U
Draw
14D
Cycle

Semax is registered as a medicine in Russia (nasal drops, 0.1% and 1%) and is not FDA-approved. No Russian label could be retrieved, so no label dose is encoded. Injectable vial use is community practice.

PTSEALEDSemax5 MGLYOPHILIZED
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Protocols

  • Short community courserecommended

    Community practice, not from a label or trial: inside the 200-600 mcg per injection range, for the 1-2 week on period.

  • Short, upper-range community course

    Community practice, not from a label or trial: top of the 200-600 mcg per injection range for the shortest on period.

Dosing

  • Russian stroke trial (Gusev 2018, 110 patients): 6000 mcg/day in 2 courses of 10 days with a 20-day interval; the route is not stated in the abstract.
  • Community practice, not from a label or trial: subcutaneous, often discussed at 200-600 mcg per injection (Outliyr); not established for clinical use.
  • Community practice, not from a label or trial: nasal 0.1% spray 300-1000 mcg/day, 1-2 times daily. Common cycle 1-2 weeks on, 1 week off (community-derived, no trial support).

Route & timing

Route: Intranasal is the marketed route. Reconstituting a lyophilized vial for subcutaneous injection is community use, not from a label or trial.

Timing: Morning and early afternoon, since later doses can disturb sleep (Outliyr).

Reconstitution

  • Lyophilized powder with bacteriostatic water; no sourced volume.
  • The water in the protocols is arithmetic for a readable draw: a 5 mg vial in 2 mL gives 2.5 mg/mL, so 300 mcg = 12 units and 600 mcg = 24 units. Not a sourced instruction. The 5000 mcg vial is a placeholder; the source gives no vial size.

Reconstitution calculator

Concentration
2500 mcg/mL
Per unit
25 mcg
Draw
12 units
Volume
0.12 mL
Doses per vial
16.67
Vials for cycle (14 doses), pooled
1
Vials, discard remainder
1
concentration = 5000 / 2 = 2500 mcg/mL
per unit = 2500 / 100 = 25 mcg
units = 300 / 25 = 12
mL = 12 / 100 = 0.12
doses per vial = 5000 / 300 = 16.667
pooled vials = ceil(300 x 14 / 5000) = 1
discard vials = ceil(14 / floor(16.667)) = 1

Stability

No reliable figure found in the sources; ask your prescriber or supplier.

Off-cycle

1 week off after 1-2 weeks on (community-derived).

Why:

  • Outliyr says this pattern is not supported by a clinical trial.

Stacking rules

  • Never draw into the same syringe as another compound; use separate syringes and distinct injection sites.
  • Avoid without clinician input if on MAOIs or psychiatric medicines (Outliyr).

Safety

Registered in Russia; not FDA-approved. US compounding status unresolved. Main practical risk is product quality: purity and concentration vary (Outliyr).

Common side effects:

  • Nasal irritation (most common), headache, restlessness, irritability, fatigue, sleep disruption, more likely at higher doses or late in the day (Outliyr; reports, not trial data).

Stop and call your prescriber if:

  • Paradoxical anxiety or agitation
  • Injection-site infection
  • Avoid without clinician input: pregnancy, breastfeeding, seizure history, unstable psychiatric symptoms

Labs and monitoring:

  • No monitoring schedule was found in the sources.

Markers to track

No reliable source names a biomarker for this compound.

Sources

Semax