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29-residue chain

Sermorelin

GHRH 1-29 fragment; formerly FDA-approved (Geref) for GH-deficient children, now compounded

200MCG
Dose
10U
Draw
84D
Cycle

Sermorelin is the first 29 amino acids of GHRH. It was FDA-approved as Geref for children with growth hormone deficiency and is no longer marketed (sources disagree on the year, 2008 or 2009, and I did not confirm the maker's reason). Adult use today is compounded and off-label, and the figures below come from a secondary source, not a label.

PTSEALEDSermorelin5 MGLYOPHILIZED
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Protocols

  • Community adult courserecommended

    Community practice, not from a label or trial. Middle of the 100-300 mcg range. Not the pediatric Geref dose, which is weight-based (30 mcg/kg).

Dosing

  • Historical pediatric (review of the evidence, not self-dosing): 30 mcg/kg subcutaneously once daily at bedtime in prepubertal children with idiopathic GH deficiency.
  • Diagnostic: a single IV dose of 1 mcg/kg as a provocative test for GH deficiency (review).
  • Community practice, not from a label or trial: adults 100-300 mcg subcutaneously once daily, about 30 minutes before bedtime on an empty stomach, in 3-6 month cycles (Peptide Protocol Wiki; says no controlled-trial protocol exists for adults).

Route & timing

Route: Subcutaneous injection.

Timing: Community: about 30 minutes before bedtime, fasted; food within 90 minutes may blunt the GH response (secondary source).

Reconstitution

  • Secondary source: bacteriostatic water, typically 2-3 mL per 5 mg vial, added slowly down the side and swirled, not shaken. The water in the protocol is arithmetic (5000 mcg + 2.5 mL gives 2000 mcg/mL, so 200 mcg = 10 units).

Reconstitution calculator

Concentration
2000 mcg/mL
Per unit
20 mcg
Draw
10 units
Volume
0.1 mL
Doses per vial
25
Vials for cycle (84 doses), pooled
4
Vials, discard remainder
4
concentration = 5000 / 2.5 = 2000 mcg/mL
per unit = 2000 / 100 = 20 mcg
units = 200 / 20 = 10
mL = 10 / 100 = 0.1
doses per vial = 5000 / 200 = 25
pooled vials = ceil(200 x 84 / 5000) = 4
discard vials = ceil(84 / floor(25)) = 4

Stability

Secondary source: after reconstitution keep at 2-8 C and use within 14 days; do not freeze.

Off-cycle

Community: 3-6 month cycles with periodic reassessment; no sourced rest period.

Why:

  • The sources give no off-cycle length.

Stacking rules

  • Never draw into the same syringe as another compound; use separate syringes and distinct injection sites.
  • No combination guidance was fetched.

Safety

Not currently an approved marketed product; the former Geref approval was pediatric. Compounded supply is unapproved and varies.

Common side effects:

  • Transient facial flushing and injection-site pain were the most common reactions; single IV and repeated subcutaneous doses were well tolerated (review).
  • Growth hormone secretagogues raise GH and IGF-1; people with active cancer, pituitary disease or diabetes should only use them under a prescriber.

Stop and call your prescriber if:

  • Swelling of face or hands, rash or trouble breathing
  • Excessive thirst or urination
  • Persistent headache or vision change

Markers to track

No reliable source names a biomarker for this compound.

Sources

Sermorelin